Orthoclone OKT3, Muromonab-CD3

Description (Brief)
Orthoclone OKT3 prevents rejection of new tissues in patients who have received kidney grafts. It was the first drug created through monoclonal antibody technology to be approved for human use.
Monoclonal antibody technology uses specially made cells as tiny factories to pump out pure sources of a single antibody. Prior to its development, it was very difficult to isolate large amounts of a single antibody for therapeutic use.
Monoclonal antibody cells are created by fusing two cells of different origins. One cell, from a mouse's spleen, produces the antibody. The other cell, from a tumor, has the ability to replicate continuously. By fusing the two cells, a new cell is created which has the best characteristics of both-it produces the antibody and also grows quickly. These new cells produce large amounts of pure antibodies which are harvested for use in drugs like Orthoclone OKT3.
The object is a clear glass 5 mL ampule with a blue ring around the neck and a clear label with blue printing. It is housed in a formfitting plastic case with snap top and snap sides.
Currently not on view
Object Name
date made
ca 1986
Ortho Pharmaceutical Corporation
Physical Description
glass (overall material)
plastic (overall material)
murine monoclonal antibody muromonab-CDE, 5 mg (drug active ingredients)
overall: 3 3/8 in x 1 1/4 in x 1 1/4 in; 8.5725 cm x 3.175 cm x 3.175 cm
overall: 3 3/8 in x 1 1/4 in x 1 3/8 in; 8.5725 cm x 3.175 cm x 3.4925 cm
place made
United States: New Jersey, Raritan
ID Number
accession number
catalog number
Recombinant Pharmaceuticals
Biotechnology and Genetics
Health & Medicine
Science & Mathematics
See more items in
Medicine and Science: Medicine
Recombinant Pharmaceuticals
Biotechnology and Genetics
Data Source
National Museum of American History, Kenneth E. Behring Center

Visitor Comments

Add a comment about this object

**Please read before submitting the form**

Have a comment or question about this object to share with the community? Please use the form below. Selected comments will appear on this page and may receive a museum response (but we can't promise). Please note that we generally cannot answer questions about the history, rarity, or value of your personal artifacts.

Have a question about anything else, or would you prefer a personal response? Please visit our FAQ or contact page.

Personal information will not be shared or result in unsolicited e-mail. See our privacy policy.

Enter the characters shown in the image.