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Orthoclone OKT3 Muromonab-CD3

Orthoclone OKT3 Muromonab-CD3

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Description (Brief)
Orthoclone OKT3 prevents rejection of new tissues in patients who have received kidney grafts. It was the first drug created through monoclonal antibody technology to be approved for human use.
Monoclonal antibody technology uses specially made cells as tiny factories to pump out pure sources of a single antibody. Prior to its development, it was very difficult to isolate large amounts of a single antibody for therapeutic use.
Monoclonal antibody cells are created by fusing two cells of different origins. One cell, from a mouse's spleen, produces the antibody. The other cell, from a tumor, has the ability to replicate continuously. By fusing the two cells, a new cell is created which has the best characteristics of both-it produces the antibody and also grows quickly. These new cells produce large amounts of pure antibodies which are harvested for use in drugs like Orthoclone OKT3.
The object is a clear glass 5 mL ampule with a blue ring around the neck and a clear label with blue printing. It is housed in a formfitting plastic case with snap top and snap sides.
Currently not on view
Object Name
date made
ca 1986
Ortho Pharmaceutical Corporation
place made
United States: New Jersey, Raritan
Physical Description
glass (container material)
plastic (packaging material)
murine monoclonal antibody muromonab-CDE, 5 mg (drug ingredient)
overall: 3 3/8 in x 1 1/4 in x 1 1/4 in; 8.5725 cm x 3.175 cm x 3.175 cm
overall: 3 3/8 in x 1 1/4 in x 1 3/8 in; 8.5725 cm x 3.175 cm x 3.4925 cm
ID Number
accession number
catalog number
Credit Line
Gift of Ortho Pharmaceutical Corporation
See more items in
Medicine and Science: Medicine
Recombinant Pharmaceuticals
Science & Mathematics
Biotechnology and Genetics
Health & Medicine
The Antibody Initiative
Antibody Initiative: Monoclonal Antibodies
Data Source
National Museum of American History
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