Smithsonian museums continue to be closed to support the effort to contain the spread of COVID-19. Read a message from our director, and check our website and social media for updates.

Activase for intravenous use, 100 mg; Alteplase recombinant

Activase for intravenous use, 100 mg; Alteplase recombinant

<< >>
Usage conditions apply
Downloads
Description (Brief)
Activase is a recombinant pharmaceutical that is administered intravenously. Approved by the FDA on November 13, 1987, it contains tissue plasminogen activator (tPA), an enzyme that helps dissolve blood clots. Although Activase was originally developed to treat heart attack (acute myocardial infarction), it is now also used to treat stroke (acute ischemic stroke) and blood clots in the lungs (pulmonary embolism).
Recombinant pharmaceuticals are created by inserting genes from one species into a host species, often yeast or bacteria, where they do not naturally occur. The genes code for a desired product, and therefore the genetically modified host organisms can be grown and used as a kind of living factory to produce the product. In this case, genes coding for tPA are inserted into cultured Chinese hamster ovary cells. The ovary cells produce tPA, which is harvested and used as the active ingredient in Activase.
Object consists of a white cardboard box with red and blue printing. Box contains two round, clear glass bottles, two product inserts, and one "Transofix" transfer device. One bottle contains sterile water for injection and has a plastic magenta lid and white label with black print. One bottle contains Activase and has plastic blue lid, a white label with blue and red printing and a white plastic base. The Transofix device is used to mix the sterile water and powdered Activase to reconstitute the medicine for administration.
Location
Currently not on view
Object Name
pharmaceutical
date made
before 1994
maker
Genentech, Inc.
place made
United States: California, South San Francisco
Physical Description
alteplase, 100 mg (58 million IU) (drug active ingredients)
Measurements
overall: 4 1/4 in x 5 1/8 in x 2 1/4 in; 10.795 cm x 13.0175 cm x 5.715 cm
sterile water: 9.7 cm x 4.7 cm; 3 13/16 in x 1 27/32 in
powder bottle: 10.2 cm x 5.7 cm; 4 1/32 in x 2 1/4 in
transfer device: 2 cm x 9.6 cm x 6.5 cm; 25/32 in x 3 25/32 in x 2 9/16 in
ID Number
2012.0046.42
catalog number
2012.0046.42
accession number
2012.0046
See more items in
Medicine and Science: Medicine
Recombinant Pharmaceuticals
Science & Mathematics
Biotechnology and Genetics
Health & Medicine
Data Source
National Museum of American History
Nominate this object for photography.   

Our collection database is a work in progress. We may update this record based on further research and review. Learn more about our approach to sharing our collection online.

If you would like to know how you can use content on this page, see the Smithsonian's Terms of Use. If you need to request an image for publication or other use, please visit Rights and Reproductions.

Comments

Add a comment about this object