Humulin L, LENTE

Humulin L, LENTE

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Description (Brief)
Humulin is human insulin used for treating diabetes. Prior to its development, diabetics used insulin isolated from pig and cow pancreases. Developed by Genentech, the first American biotechnology company, Humulin was licensed to Eli Lilly and became the first marketable product created through recombinant DNA technology. Its licensing by the FDA in October 1982 also made it the first recombinant pharmaceutical approved for use in the United States.
Recombinant pharmaceuticals are created by inserting genes from one species into a host species, often yeast or bacteria, where they do not naturally occur. The genes code for a desired product, and therefore the genetically modified host organisms can be grown and used as a kind of living factory to produce the product. In this case, genes coding for human insulin are inserted into bacteria. Bacteria produce insulin, which is harvested and used as the active ingredient in Humulin.
Humulin L is an intermediate-acting insulin with a slower onset of action than regular insulin and a longer duration of activity (up to 24 hours). Due to declining use of longer-acting insulins, Humulin L was discontinued in 2005.
Object is a sealed white cardboard box with black and red printing.
Location
Currently not on view
Object Name
pharmaceutical
biological
insulin
date made
before March 1995
maker
Eli Lilly and Company
place made
United States: Indiana, Indianapolis
Physical Description
human insulin (overall material)
Measurements
overall: 2 3/4 in x 1 3/8 in x 1 3/8 in; 6.985 cm x 3.4925 cm x 3.4925 cm
overall: 1 5/16 in x 2 7/8 in x 1 5/16 in; 3.33375 cm x 7.3025 cm x 3.33375 cm
ID Number
2012.0046.46
accession number
2012.0046
catalog number
2012.0046.46
See more items in
Medicine and Science: Medicine
Recombinant Pharmaceuticals
Science & Mathematics
Biotechnology and Genetics
Health & Medicine
Diabetes
Data Source
National Museum of American History
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