Technical Manual for Posilac

Technical Manual for Posilac

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Description (Brief)
Posilac is a recombinant pharmaceutical used to increase milk production in lactating dairy cows. Approved by the FDA in 1993, Posilac was the first biotechnology product offered for sale by Monsanto. The company sold the rights to Elanco, a division of Eli Lilly and Company in 2008.
Its active ingredient, bovine growth hormone-also known as rBGH and rBST-has been at the center of ongoing controversy in the United States. Although deemed safe by the FDA, rBGH is banned in many other countries. American consumer groups have countered FDA claims of safety with concerns about possible health risks stemming from differences between milk produced by cows treated with rBGH and milk produced by untreated cows.
Recombinant pharmaceuticals like Posilac are created by inserting genes from one species into a host species, often yeast or bacteria, where they do not naturally occur. The genes code for a desired product, and therefore the genetically modified host organisms can be grown and used as a kind of living factory to produce the product. In this case, genes coding for bovine growth hormone are inserted into bacteria. Bacteria produce the somatotropin, which is harvested and used as the active ingredient in Posilac.
Object consist of a white plastic three-ring binder with image of three milk trucks on front. Binder sections are separated by blue tabs. Binder sections include: 1. Posilac-- An Introduction; 2. Posilac-- Milk Production and Management; 3. Posilac and Economics; 4. Posilac and Nutrition; 5. Posilac and Reproduction; 6. Posilac and Mastitis; 7. Posilac and Genetics; 8. Posilac Manufacturing and Mode of Action; 9. Posilac and Human Safety; 10. Posilac and Cow Safety; 11. Posilac in Other Countries; Notes
Currently not on view
Object Name
date made
Monsanto Company
Physical Description
plastic (overall material)
paper (overall material)
metal (overall material)
overall: 11 1/2 in x 12 1/4 in x 1 1/2 in; 29.21 cm x 31.115 cm x 3.81 cm
ID Number
catalog number
accession number
See more items in
Medicine and Science: Medicine
Recombinant Pharmaceuticals
Science & Mathematics
Biotechnology and Genetics
Health & Medicine
Data Source
National Museum of American History
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