Diagram of a Nuclear plant in the Hydro-Québec system
Uranium is made into ceramic pellets and loaded into fuel-rods. A number of rods are packed together into bundles. A coolant (in this case, heavy water*) flows around the bundles and picks up heat generated by the fissioning uranium. This now heated coolant is pumped though boiler-tubes, creating steam by passing its heat to ordinary water in a boiler. Electricity is then generated just as in a fossil-fuel plant.

*Heavy water is simply ordinary H2O in which the hydrogen atoms each have a neutron to go with their proton and electron. This form of hydrogen is also called Deuterium.
Image copyright, Hydro-Québec

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